Is calmodulin inhibition involved in shape transformations induced by amphiphiles in erythrocytes?
Biochim Biophys Acta
; 940(1): 121-6, 1988 May 09.
Article
em En
| MEDLINE
| ID: mdl-2835099
ABSTRACT
Potent antihaemolytic and shape transforming amphiphilic compounds were studied for their ability to inhibit calmodulin-activated phosphodiesterase activity. Some echinocytogenic and stomatocytogenic amphiphiles were potent calmodulin inhibitors. The most potent echinocytogenic and stomatocytogenic amphiphiles, however, had no or only weak inhibitory effect. Our results show that there is no causal relationship between the ability of amphiphiles to induce antihaemolysis or shape transformations in erythrocytes and their ability to inhibit calmodulin-activated phosphodiesterase activity, and it is suggested that calmodulin is not involved in shape transformations induced by amphiphiles.
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Base de dados:
MEDLINE
Assunto principal:
Calmodulina
/
Bloqueadores dos Canais de Cálcio
/
Eritrócitos
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Finlândia