A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity.
Angew Chem Int Ed Engl
; 56(18): 5031-5034, 2017 04 24.
Article
em En
| MEDLINE
| ID: mdl-28370842
ABSTRACT
A membrane-intercalating conjugated oligoelectrolyte (COE), PTTP, was designed and synthesized with the goal of providing red-shifted absorption spectra relative to previously synthesized COE analogs. Specifically, electron-rich and electron-poor subunits were introduced in the conjugated backbone to modulate the band gap. PTTP exhibits maxima of absorption at 507â
nm and of emission at 725â
nm. PTTP can also efficiently function to generate singlet oxygen in situ (ΦΔ ≈20 %) and has appropriate topology and dimensions to interact with lipid membranes. The resulting rapid membrane insertion and sensitizing ability provide PTTP with a highly efficient antibacterial capability under a low light dose (0.6â
J cm-2 ) toward Gram-negative bacteria E. coli, making it a remarkably efficient optically mediated antimicrobial agent.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fármacos Fotossensibilizantes
/
Escherichia coli
/
Bicamadas Lipídicas
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos