Immunological response to Mycobacterium tuberculosis infection in blood from type 2 diabetes patients.
Immunol Lett
; 186: 41-45, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28377108
ABSTRACT
The convergence of tuberculosis and diabetes represents a co-epidemic that threatens progress against tuberculosis. We have investigated type 2 diabetes as a risk factor for tuberculosis susceptibility, and have used as experimental model whole blood infected in vitro with Mycobacterium tuberculosis. Blood samples from diabetic patients were found to have a higher absolute neutrophil count that non-diabetic controls, but their immune functionality seemed impaired because they displayed a lower capacity to phagocytose M. tuberculosis, a finding that had been previously reported only for monocytes. In contrast, an increased production of TNFα was detected in infected blood from diabetic patients. Despite the altered phagocytic capacity showed by cells from these patients, the antimicrobial activity measured in both whole blood and monocyte derived macrophages was similar to that of controls. This unexpected result prompts further improvements in the whole blood model to analyze the immune response of diabetes patients to tuberculosis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose
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Células Sanguíneas
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Diabetes Mellitus Tipo 2
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Macrófagos
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Mycobacterium tuberculosis
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Neutrófilos
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha