Correlation between early-life regulation of the immune system by microbiota and allergy development.
J Allergy Clin Immunol
; 139(4): 1084-1091, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28390575
ABSTRACT
Early postnatal life is a key time for development of the immune system and colonization of the host by microbiota. Recent studies have shown that specific limbs of the immune system can be regulated by microbiota in a time-restricted period during early life. Studies in mouse models have shown that perturbations of the microbiota during early life can cause immune effects that can persist into adulthood and create increased host susceptibility to certain diseases. Here we discuss the role of early-life regulation of the immune system by the microbiota and how it can be related to allergy development.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Microbiota
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Hipersensibilidade
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Sistema Imunitário
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Mucosa
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Allergy Clin Immunol
Ano de publicação:
2017
Tipo de documento:
Article