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A Scalable and Versatile Synthesis of Oxime-Based Hormone Dimers and Gels for Sustained Release.
Bennett, Christopher W; Collins, Joe; Xiao, Zeyun; Klinger, Daniel; Connal, Luke A.
Afiliação
  • Bennett CW; The Department of Chemical and Biomolecular Engineering, The University of Melbourne, Melbourne, 3010, Australia.
  • Collins J; The Department of Chemical and Biomolecular Engineering, The University of Melbourne, Melbourne, 3010, Australia.
  • Xiao Z; The Department of Chemical and Biomolecular Engineering, The University of Melbourne, Melbourne, 3010, Australia.
  • Klinger D; Institute of Pharmacy, Freie University Berlin, Königin-Luise-Str. 2-4, 14195, Berlin, Germany.
  • Connal LA; The Department of Chemical and Biomolecular Engineering, The University of Melbourne, Melbourne, 3010, Australia.
Chem Asian J ; 12(13): 1456-1460, 2017 Jul 04.
Article em En | MEDLINE | ID: mdl-28417588
ABSTRACT
Well-defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol- and progesterone-dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone-based organogels. Owing to the dynamic nature of the oxime bond, the hormone-based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Hormônios Idioma: En Revista: Chem Asian J Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Hormônios Idioma: En Revista: Chem Asian J Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália