A Scalable and Versatile Synthesis of Oxime-Based Hormone Dimers and Gels for Sustained Release.
Chem Asian J
; 12(13): 1456-1460, 2017 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-28417588
ABSTRACT
Well-defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol- and progesterone-dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone-based organogels. Owing to the dynamic nature of the oxime bond, the hormone-based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Hormônios
Idioma:
En
Revista:
Chem Asian J
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Austrália