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Dasatinib Use and Risk of Cytomegalovirus Reactivation After Allogeneic Hematopoietic-Cell Transplantation.
Prestes, Daniel P; Arbona, Esther; Nevett-Fernandez, Alexandra; Woolley, Ann E; Ho, Vincent T; Koo, Sophia; Baden, Lindsey R; Koreth, John; Hammond, Sarah P; Issa, Nicolas C; Marty, Francisco M.
Afiliação
  • Prestes DP; Division of Infectious Diseases, Brigham and Women's Hospital.
  • Arbona E; Division of Infectious Diseases, Brigham and Women's Hospital.
  • Nevett-Fernandez A; Division of Infectious Diseases, Brigham and Women's Hospital.
  • Woolley AE; Division of Infectious Diseases, Brigham and Women's Hospital.
  • Ho VT; Division of Medical Oncology, Dana-Farber Cancer Institute.
  • Koo S; Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  • Baden LR; Division of Infectious Diseases, Brigham and Women's Hospital.
  • Koreth J; Division of Medical Oncology, Dana-Farber Cancer Institute.
  • Hammond SP; Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  • Issa NC; Division of Infectious Diseases, Brigham and Women's Hospital.
  • Marty FM; Division of Medical Oncology, Dana-Farber Cancer Institute.
Clin Infect Dis ; 65(3): 510-513, 2017 Aug 01.
Article em En | MEDLINE | ID: mdl-28419210
Viral infections have been reported with dasatinib use, but its cytomegalovirus risk after hematopoietic-cell transplantation (HCT) is not known. We found that post-HCT dasatinib use increased the risk of cytomegalovirus reactivation (adjusted hazard ratio, 7.65; 95% confidence interval, 1.84-31.7), controlling for acute graft-versus-host disease, in 109 patients with Philadelphia-chromosome-positive malignancies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Citomegalovirus / Transplante de Células-Tronco Hematopoéticas / Citomegalovirus / Dasatinibe / Antineoplásicos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Citomegalovirus / Transplante de Células-Tronco Hematopoéticas / Citomegalovirus / Dasatinibe / Antineoplásicos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article