Feasibility of uterine preservation in the management of early-stage uterine adenosarcomas: a single institute experience.
World J Surg Oncol
; 15(1): 87, 2017 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-28424089
ABSTRACT
BACKGROUND:
We aimed to evaluate the efficacy and the safety of uterine preservation in patients with early-stage uterine adenosarcoma who want to preserve future fertility.METHODS:
We performed a retrospective review of patients with stage I uterine adenosarcoma diagnosed and treated at a single institute from 1998 through 2014.RESULTS:
Among the total of 31 patients, uterine preservation surgery was performed in 7 of the nulliparas. Of the 7 patients receiving uterine preservation surgery, 3 showed no evidence of disease (NED), 2 had persistent disease confined to the uterus, and 2 were alive with disease (AWD) after recurrence. One patient with an NED status had a vaginal delivery at term. In the uterine preservation group, 1 patient had sarcomatous overgrowth at the time of diagnosis and experienced disease recurrence. In the hysterectomy group, 3 of 24 patients had tumor recurrence. Of the five patients with tumor recurrence, four (80%) had sarcomatous overgrowth at diagnosis and it was significantly associated with recurrence by univariate analysis (OR 13.3, p = 0.027).CONCLUSIONS:
Uterine preservation represents a possible treatment option for young female patients who want to maintain fertility. However, a detailed explanation of the risk of recurrence is necessary, especially in patients with sarcomatous overgrowth, which seems to be associated with a higher risk of recurrence. TRIAL REGISTRATION Retrospectively registered.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preservação de Órgãos
/
Procedimentos Cirúrgicos em Ginecologia
/
Neoplasias Uterinas
/
Adenossarcoma
/
Tratamentos com Preservação do Órgão
/
Preservação da Fertilidade
/
Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
World J Surg Oncol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Coréia do Sul