Lysibodies are IgG Fc fusions with lysin binding domains targeting <i>Staphylococcus aureus</i> wall carbohydrates for effective phagocytosis.

Raz, Assaf; Serrano, Anna; Lawson, Christine; Thaker, Maneesha; Alston, Tricia; Bournazos, Stylianos; Ravetch, Jeffrey V; Fischetti, Vincent A

Lysibodies are IgG Fc fusions with lysin binding domains targeting Staphylococcus aureus wall carbohydrates for effective phagocytosis.

Raz, Assaf; Serrano, Anna; Lawson, Christine; Thaker, Maneesha; Alston, Tricia; Bournazos, Stylianos; Ravetch, Jeffrey V; Fischetti, Vincent A.

Afiliação

Raz A; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065; araz@rockefeller.edu.
Serrano A; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065.
Lawson C; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065.
Thaker M; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065.
Alston T; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065.
Bournazos S; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065.
Ravetch JV; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065.
Fischetti VA; Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065.

Proc Natl Acad Sci U S A ; 114(18): 4781-4786, 2017 05 02.

Article em En | MEDLINE | ID: mdl-28428342

Assuntos

Parede Celular/metabolismo; Fragmentos Fc das Imunoglobulinas/farmacologia; N-Acetil-Muramil-L-Alanina Amidase/farmacologia; Fagocitose/efeitos dos fármacos; Polissacarídeos Bacterianos/metabolismo; Proteínas Recombinantes de Fusão/farmacologia; Staphylococcus aureus/metabolismo; Células HL-60; Humanos; Fragmentos Fc das Imunoglobulinas/genética; N-Acetil-Muramil-L-Alanina Amidase/genética; Polissacarídeos Bacterianos/antagonistas & inibidores; Proteínas Recombinantes de Fusão/genética

Palavras-chave

antibody; immunotherapy; monoclonal; peptidoglycan hydrolase; vaccine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fagocitose / Polissacarídeos Bacterianos / Staphylococcus aureus / Proteínas Recombinantes de Fusão / Fragmentos Fc das Imunoglobulinas / Parede Celular / N-Acetil-Muramil-L-Alanina Amidase Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article

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