High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model.
Stem Cell Rev Rep
; 13(3): 335-346, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28429185
ABSTRACT
Drug discovery and development continues to be a challenge to the pharmaceutical industry despite great advances in cell and molecular biology that allow for the design of better targeted therapeutics. Many potential drug compounds fail during the clinical trial due to inefficacy and toxicity that were not predicted during preclinical stages. The fundamental problem lies with the use of traditional drug screening models that still largely rely on the use of cell lines or animal cell monolayers, which leads to lack of predictive power of human tissue and organ response to the drug candidates. More physiologically relevant systems are therefore critical in relieving the burden of high failure rates. Emerging knowledge and techniques in tissue engineering and microfabrication have enabled the development of micro-engineered systems - collectively known as organs-on-chips - that may lead to a paradigm shift in preclinical drug screening assays. In this review we explore the technological advances and challenges in the development of heart-on-a-chip models, by addressing current assessment methods for drug-induced cardiotoxicity and providing a perspective on the modifications that should be implemented to realize the full potential of this system.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Avaliação Pré-Clínica de Medicamentos
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Dispositivos Lab-On-A-Chip
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Modelos Cardiovasculares
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Miocárdio
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Screening_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Stem Cell Rev Rep
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá