Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach.

Grewal, Gurpreet K; Singh, Khuraijam D; Kanojia, Neha; Rawat, Chitra; Kukal, Samiksha; Jajodia, Ajay; Singhal, Anshika; Misra, Richa; Nagamani, Selvaraman; Muthusamy, Karthikeyan; Kukreti, Ritushree

Grewal, Gurpreet K; Singh, Khuraijam D; Kanojia, Neha; Rawat, Chitra; Kukal, Samiksha; Jajodia, Ajay; Singhal, Anshika; Misra, Richa; Nagamani, Selvaraman; Muthusamy, Karthikeyan; Kukreti, Ritushree.

Afiliação

Grewal GK; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, New Delhi, India.
Singh KD; Genomics and Molecular Medicine Unit,, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110 007, India.
Kanojia N; Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, 630 004, India.
Rawat C; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, New Delhi, India.
Kukal S; Genomics and Molecular Medicine Unit,, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110 007, India.
Jajodia A; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, New Delhi, India.
Singhal A; Genomics and Molecular Medicine Unit,, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110 007, India.
Misra R; Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, New Delhi, India.
Nagamani S; Genomics and Molecular Medicine Unit,, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110 007, India.
Muthusamy K; Genomics and Molecular Medicine Unit,, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110 007, India.
Kukreti R; Genomics and Molecular Medicine Unit,, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi, 110 007, India.

Pharm Res ; 34(7): 1444-1458, 2017 Jul.

Article em En | MEDLINE | ID: mdl-28432535

Assuntos

Anticonvulsivantes/química; Carbamazepina/química; Proteínas Associadas à Resistência a Múltiplos Medicamentos/química; Receptores de Esteroides/química; Transporte Ativo do Núcleo Celular; Anticonvulsivantes/metabolismo; Anticonvulsivantes/farmacologia; Ligação Competitiva; Carbamazepina/farmacologia; Núcleo Celular/metabolismo; Simulação por Computador; Células Hep G2; Humanos; Cetoconazol/química; Cetoconazol/farmacologia; Ligantes; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Proteína 2 Associada à Farmacorresistência Múltipla; Proteínas Associadas à Resistência a Múltiplos Medicamentos/metabolismo; Mutação; Floroglucinol/análogos & derivados; Floroglucinol/química; Floroglucinol/farmacologia; Receptor de Pregnano X; Ligação Proteica; Interferência de RNA; Receptores de Esteroides/agonistas; Receptores de Esteroides/antagonistas & inibidores; Receptores de Esteroides/genética; Terpenos/química; Terpenos/farmacologia

Palavras-chave

ABCC2; carbamazepine; molecular dynamics simulation; pregnane xenobiotic receptor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbamazepina / Receptores de Esteroides / Proteínas Associadas à Resistência a Múltiplos Medicamentos / Anticonvulsivantes Limite: Humans Idioma: En Revista: Pharm Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google