Signaling pathways regulating blood-tissue barriers - Lesson from the testis.
Biochim Biophys Acta Biomembr
; 1860(1): 141-153, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28450047
ABSTRACT
Signaling pathways that regulate blood-tissue barriers are important for studying the biology of various blood-tissue barriers. This information, if deciphered and better understood, will provide better therapeutic management of diseases particularly in organs that are sealed by the corresponding blood-tissue barriers from systemic circulation, such as the brain and the testis. These barriers block the access of antibiotics and/or chemotherapeutical agents across the corresponding barriers. Studies in the last decade using the blood-testis barrier (BTB) in rats have demonstrated the presence of several signaling pathways that are crucial to modulate BTB function. Herein, we critically evaluate these findings and provide hypothetical models regarding the underlying mechanisms by which these signaling molecules/pathways modulate BTB dynamics. This information should be carefully evaluated to examine their applicability in other tissue barriers which shall benefit future functional studies in the field. This article is part of a Special Issue entitled Gap Junction Proteins edited by Jean Claude Herve.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Barreira Hematotesticular
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Transdução de Sinais
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Junções Comunicantes
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Conexinas
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Modelos Cardiovasculares
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Biochim Biophys Acta Biomembr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos