Rhomboid proteases in human disease: Mechanisms and future prospects.
Biochim Biophys Acta Mol Cell Res
; 1864(11 Pt B): 2200-2209, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28460881
ABSTRACT
Rhomboids are intramembrane serine proteases that cleave the transmembrane helices of substrate proteins, typically releasing luminal/extracellular domains from the membrane. They are conserved in all branches of life and there is a growing recognition of their association with a wide range of human diseases. Human rhomboids, for example, have been implicated in cancer, metabolic disease and neurodegeneration, while rhomboids in apicomplexan parasites appear to contribute to their invasion of host cells. Recent advances in our knowledge of the structure and the enzyme function of rhomboids, and increasing efforts to identify specific inhibitors, are beginning to provide important insight into the prospect of rhomboids becoming future therapeutic targets. This article is part of a Special Issue entitled Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Serina Proteases
/
Proteólise
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Mol Cell Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido