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Design and optimization of purine derivatives as in vivo active PDE10A inhibitors.
Chen, Liu; Chen, Danqi; Tang, Le; Ren, Jing; Chen, Jiaojiao; Zhen, Xuechu; Liu, Yu-Chih; Zhang, Chenhua; Luo, Haibin; Shen, Jingkang; Xiong, Bing.
Afiliação
  • Chen L; School of PharmaceuticalSciences, Nanchang University, Nanchang 330006, China; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Chen D; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Tang L; School of PharmaceuticalSciences, Nanchang University, Nanchang 330006, China; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Ren J; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Chen J; Department of Pharmacology, Soochow University College of Pharmaceutical Sciences, Suzhou, China.
  • Zhen X; Department of Pharmacology, Soochow University College of Pharmaceutical Sciences, Suzhou, China.
  • Liu YC; Shanghai ChemPartner Co., LTD, Building 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China.
  • Zhang C; Shanghai ChemPartner Co., LTD, Building 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China.
  • Luo H; School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China.
  • Shen J; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: jkshen@simm.ac.cn.
  • Xiong B; Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: bxiong@simm.ac.cn.
Bioorg Med Chem ; 25(13): 3315-3329, 2017 07 01.
Article em En | MEDLINE | ID: mdl-28462841
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Purinas / Desenho de Fármacos / Diester Fosfórico Hidrolases Limite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Purinas / Desenho de Fármacos / Diester Fosfórico Hidrolases Limite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China