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Involvement of Nrf2 in Ocular Diseases.
Batliwala, Shehzad; Xavier, Christy; Liu, Yang; Wu, Hongli; Pang, Iok-Hou.
Afiliação
  • Batliwala S; Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Xavier C; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Liu Y; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Wu H; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Pang IH; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Oxid Med Cell Longev ; 2017: 1703810, 2017.
Article em En | MEDLINE | ID: mdl-28473877
ABSTRACT
The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Estresse Oxidativo / Fator 2 Relacionado a NF-E2 / Oftalmopatias Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Estresse Oxidativo / Fator 2 Relacionado a NF-E2 / Oftalmopatias Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos