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Head-to-Head Comparison of Inflammation and Neovascularization in Human Carotid Plaques: Implications for the Imaging of Vulnerable Plaques.
Demeure, Fabian; Bouzin, Caroline; Roelants, Véronique; Bol, Anne; Verhelst, Robert; Astarci, Parla; Gerber, Bernhard L; Pouleur, Anne-Catherine; Pasquet, Agnès; de Meester, Christophe; Vanoverschelde, Jean-Louis J; Vancraeynest, David.
Afiliação
  • Demeure F; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Bouzin C; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Roelants V; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Bol A; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Verhelst R; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Astarci P; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Gerber BL; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Pouleur AC; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Pasquet A; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • de Meester C; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Vanoverschelde JJ; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
  • Vancraeynest D; From the Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium (F.D., R.V., P.A., B.L.G., A.-C.P., A.P., C.d.M., J.-L.J.V., D.V.); Cardiovascular Department, Institut Cardiovasculaire, Cliniques Universi
Circ Cardiovasc Imaging ; 10(5)2017 May.
Article em En | MEDLINE | ID: mdl-28487317
BACKGROUND: Inflammation and intraplaque neovascularization are acknowledged to be 2 features of plaque vulnerability, although their temporal expression and their respective value in predicting clinical events are poorly understood. To determine their respective temporal associations, we conducted a comprehensive assessment of inflammation and intraplaque neovascularization in the carotid plaque of symptomatic and asymptomatic patients. METHODS AND RESULTS: Thirty patients with severe carotid stenosis underwent 18F-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging. Plaque 18F-fluorodeoxyglucose-uptake, indicative of inflammation, was measured by calculating the target:background ratio. The presence of intraplaque neovascularization during contrast-enhanced ultrasound was judged semiquantitatively; low-grade contrast enhancement (CE) suggested its absence, and high-grade CE, the presence of neovascularization. Carotid surgery was performed 1.6±1.8 days after completing both imaging modalities in all patients, and the presence of macrophages and neovessels was quantified by immunohistochemistry. We identified a significant correlation between the target:background ratio and macrophage quantification (R=0.78; P<0.001). The number of vessels was also significantly higher in carotid plaque with high-CE (P<0.001). Surprisingly, immunohistochemistry showed that high-CE and vessel number were neither associated with an elevated target:background ratio (P=0.28 and P=0.60, respectively) nor macrophage infiltration (P=0.59 and P=0.40, respectively). Finally, macrophage infiltration and target:background ratio were higher in the carotid plaque of symptomatic patients (P=0.021 and P=0.05, respectively), whereas CE grade and the presence of neovessels were not. CONCLUSIONS: Inflammation and intraplaque neovascularization are not systematically associated in carotid plaques, suggesting a temporal separation between the 2 processes. Inflammation seems more pronounced when symptoms are present. These data highlight the challenges that face any imaging strategy designed to assess plaque vulnerability.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estenose das Carótidas / Placa Aterosclerótica / Inflamação / Neovascularização Patológica Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Circ Cardiovasc Imaging Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estenose das Carótidas / Placa Aterosclerótica / Inflamação / Neovascularização Patológica Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Circ Cardiovasc Imaging Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Ano de publicação: 2017 Tipo de documento: Article