R-Ras deficiency does not affect papain-induced IgE production in mice.
Immun Inflamm Dis
; 5(3): 280-288, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-28497586
ABSTRACT
INTRODUCTION:
R-Ras GTPase has recently been implicated in the regulation of immune functions, particularly in dendritic cell (DC) maturation, immune synapse formation, and subsequent T cell responses.METHODS:
Here, we investigated the role of R-Ras in allergen-induced immune response (type 2 immune response) in Rras deficient (R-Ras KO) and wild type (WT) mice.RESULTS:
Initially, we found that the number of conventional DC's in the lymph nodes (LNs) was reduced in R-Ras KO mice. The expression of co-stimulatory CD80 and CD86 molecules on these cells was also reduced on DC's from the R-Ras KO mice. However, there was no difference in papain-induced immune response between the R-Ras WT and KO as measured by serum IgE levels after the immunization. Interestingly, neither the DC number nor co-stimulatory molecule expression was different between WT and R-Ras KO animals after the immunization.CONCLUSIONS:
Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice. To our knowledge, this is the first report addressing potential differences in in vivo allergen responses regulated by the R-Ras GTPase.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Papaína
/
Proteínas ras
/
Hipersensibilidade
Limite:
Animals
Idioma:
En
Revista:
Immun Inflamm Dis
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Finlândia