The role of systemic and topical fatty acids for dry eye treatment.
Prog Retin Eye Res
; 61: 23-34, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28532687
ABSTRACT
Dry eye is a prevalent condition and one of the main reasons for patients to seek ophthalmic medical care. A low systemic level of omega fatty acids is a risk factor for dry eye disease (DED). There are two groups of essential fatty acids (EFAs) the omega-6 (n-6) family and the omega-3 (n-3) family. Humans evolved on a diet in which the n-6n-3 ratio was approximately 11, however the current Western diet tends to be deficient in n-3 EFAs and this ratio is typically much higher (approaching 171). The metabolism of EFAs generates four new families of local acting mediators lipoxins, resolvins, protectins, and maresins. These molecules have anti-inflammatory and pro-resolution properties. We present a critical overview of animal model studies and human clinical trials that have shown that dietary modification and oral supplementation could be complementary therapeutic strategies for the treatment of dry eye. Furthermore, we discuss preliminary results of the topical application of n-3 and n-6 EFAs because these molecules may act as natural anti-inflammatory agents with positive changes of the entire ocular surface system.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gorduras na Dieta
/
Ácidos Graxos Essenciais
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Síndromes do Olho Seco
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Retin Eye Res
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article