Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.

Schwalbe, Edward C; Lindsey, Janet C; Nakjang, Sirintra; Crosier, Stephen; Smith, Amanda J; Hicks, Debbie; Rafiee, Gholamreza; Hill, Rebecca M; Iliasova, Alice; Stone, Thomas; Pizer, Barry; Michalski, Antony; Joshi, Abhijit; Wharton, Stephen B; Jacques, Thomas S; Bailey, Simon; Williamson, Daniel; Clifford, Steven C

Schwalbe, Edward C; Lindsey, Janet C; Nakjang, Sirintra; Crosier, Stephen; Smith, Amanda J; Hicks, Debbie; Rafiee, Gholamreza; Hill, Rebecca M; Iliasova, Alice; Stone, Thomas; Pizer, Barry; Michalski, Antony; Joshi, Abhijit; Wharton, Stephen B; Jacques, Thomas S; Bailey, Simon; Williamson, Daniel; Clifford, Steven C.

Afiliação

Schwalbe EC; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK.
Lindsey JC; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Nakjang S; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Crosier S; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Smith AJ; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Hicks D; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Rafiee G; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Hill RM; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Iliasova A; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK.
Stone T; Neural Development Unit, UCL Institute of Child Health, London, UK.
Pizer B; Institute of Translational Research, University of Liverpool, Liverpool, UK.
Michalski A; Department of Haematology and Oncology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Joshi A; Department of Neuropathology, Royal Victoria Infirmary, Newcastle University Teaching Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Jacques TS; Neural Development Unit, UCL Institute of Child Health, London, UK.
Bailey S; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Williamson D; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Clifford SC; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK. Electronic address: steve.clifford@ncl.ac.uk.

Lancet Oncol ; 18(7): 958-971, 2017 07.

Article em En | MEDLINE | ID: mdl-28545823

Assuntos

Neoplasias Cerebelares/classificação; Neoplasias Cerebelares/genética; Metilação de DNA; Meduloblastoma/classificação; Meduloblastoma/genética; Transcriptoma; Adolescente; Fatores Etários; Neoplasias Cerebelares/patologia; Neoplasias Cerebelares/radioterapia; Criança; Pré-Escolar; Intervalo Livre de Doença; Feminino; Amplificação de Genes; Humanos; Lactente; Recém-Nascido; Fatores de Transcrição Kruppel-Like/genética; Masculino; Meduloblastoma/patologia; Meduloblastoma/radioterapia; Mutação; Proteína Proto-Oncogênica N-Myc/genética; Proteínas Nucleares/genética; Receptor Patched-1/genética; Proteínas Proto-Oncogênicas c-myc/genética; Proteínas Repressoras/genética; Estudos Retrospectivos; Medição de Risco/métodos; Fatores de Risco; Receptor Smoothened/genética; Taxa de Sobrevida; Telomerase/genética; Proteína Supressora de Tumor p53/genética; Proteína Gli2 com Dedos de Zinco; beta Catenina/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cerebelares / Metilação de DNA / Transcriptoma / Meduloblastoma Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

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