Hemispheric language organization after congenital left brain lesions: A comparison between functional transcranial Doppler and functional MRI.
J Neuropsychol
; 13(1): 46-66, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-28568707
ABSTRACT
This study investigated whether functional transcranial Doppler ultrasound (fTCD) is a suitable tool for studying hemispheric lateralization of language in patients with pre-perinatal left hemisphere (LH) lesions and right hemiparesis. Eighteen left-hemisphere-damaged children and young adults and 18 healthy controls were assessed by fTCD and fMRI to evaluate hemispheric activation during two language tasks a fTCD animation description task and a fMRI covert rhyme generation task. Lateralization indices (LIs), measured by the two methods, differed significantly between the two groups, for a clear LH dominance in healthy participants and a prevalent activation of right hemisphere in more than 80% of brain-damaged patients. Distribution of participants in terms of left, right, and bilateral lateralization was highly concordant between fTCD and fMRI values. Moreover, right hemisphere language dominance in patients with left hemispheric lesions was significantly associated with severity of cortical and subcortical damage in LH. This study suggests that fTCD is an easily applicable tool that might be a valid alternative to fMRI for large-scale studies of patients with congenital brain lesions.
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1
Base de dados:
MEDLINE
Assunto principal:
Dano Encefálico Crônico
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Idioma
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
J Neuropsychol
Assunto da revista:
NEUROLOGIA
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PSICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália