Interaction of estramustine phosphate with microtubule-associated proteins.
FEBS Lett
; 179(2): 289-93, 1985 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-2857133
ABSTRACT
We have reported [(1984) Cancer Res., in press] that estramustine phosphate inhibits microtubule assembly and disassembled preformed microtubules. We now present evidence that estramustine phosphate inhibits microtubule assembly by binding to the microtubule-associated proteins. We have found that additional microtubule-associated proteins relieved the inhibition of assembly by estramustine phosphate; 3H-labelled estramustine phosphate bound predominantly to the microtubule-associated proteins; and the content of the microtubule-associated proteins was reduced in taxol reversed estramustine phosphate-inhibited microtubules.
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Base de dados:
MEDLINE
Assunto principal:
Estramustina
/
Proteínas Associadas aos Microtúbulos
/
Microtúbulos
/
Compostos de Mostarda Nitrogenada
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1985
Tipo de documento:
Article