A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles.
Sci Rep
; 7(1): 3736, 2017 06 16.
Article
em En
| MEDLINE
| ID: mdl-28623267
ABSTRACT
Monoclonal antibodies have deserved a remarkable interest for more than 40 years as a vital tool for the treatment of various diseases. Still, there is a raising interest to develop advanced monoclonal antibody delivery systems able to tailor pharmacokinetics. Bevacizumab is a humanized immunoglobulin IgG1 used in antiangiogenic therapies due to its capacity to inhibit the interaction between vascular endothelial growth factor and its receptor. However, bevacizumab-based antiangiogenic therapy is not always effective due to poor treatment compliance associated to multiples administrations and drug resistance. In this work, we show a promising strategy of encapsulating bevacizumab to protect and deliver it, in a controlled manner, increasing the time between administrations and formulation shelf-life. Nanoencapsulation of bevacizumab represents a significant advance for selective antiangiogenic therapies since extracellular, cell surface and intracellular targets can be reached. The present study shows that bevacizumab-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles does not impair its native-like structure after encapsulation and fully retain the bioactivity, making this nanosystem a new paradigm for the improvement of angiogenic therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
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Células Endoteliais da Veia Umbilical Humana
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Bevacizumab
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Copolímero de Ácido Poliláctico e Ácido Poliglicólico
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Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Portugal