Association of bladder adenocarcinoma and BK virus infection in a pancreatico-renal transplant recipient.
NDT Plus
; 3(3): 300-302, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-28657060
ABSTRACT
Viral infection has been related to post-transplantation tumour development, particularly Epstein-Barr virus, human papillomavirus, hepatitis B and C viruses, and herpes virus 8. Recently, BK virus (BKV) has emerged as an important cause of tumour formation in solid organ transplant recipients. BKV oncogenic potential relates to the ability to inactivate the functions of tumour suppression proteins p53 and pRB family, and induction of chromosomal aberrations. We report a case of urinary bladder adenocarcinoma in a pancreatico-renal transplant recipient which was diagnosed 2 years after BKV infection. Immunohistochemical staining for SV-40 was positive in neoplastic cells but negative in non-neoplastic cells.
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Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
NDT Plus
Ano de publicação:
2010
Tipo de documento:
Article