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Building bridges between cellular and molecular structural biology.
Patwardhan, Ardan; Brandt, Robert; Butcher, Sarah J; Collinson, Lucy; Gault, David; Grünewald, Kay; Hecksel, Corey; Huiskonen, Juha T; Iudin, Andrii; Jones, Martin L; Korir, Paul K; Koster, Abraham J; Lagerstedt, Ingvar; Lawson, Catherine L; Mastronarde, David; McCormick, Matthew; Parkinson, Helen; Rosenthal, Peter B; Saalfeld, Stephan; Saibil, Helen R; Sarntivijai, Sirarat; Solanes Valero, Irene; Subramaniam, Sriram; Swedlow, Jason R; Tudose, Ilinca; Winn, Martyn; Kleywegt, Gerard J.
Afiliação
  • Patwardhan A; Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Brandt R; Visualization Sciences Group, FEI, Mérignac, France.
  • Butcher SJ; Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Helsinki, Finland.
  • Collinson L; Electron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.
  • Gault D; Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom.
  • Grünewald K; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Hecksel C; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
  • Huiskonen JT; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Iudin A; Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Jones ML; Electron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.
  • Korir PK; Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Koster AJ; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.
  • Lagerstedt I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Lawson CL; Center for Integrative Proteomics Research and the Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Piscataway, United States.
  • Mastronarde D; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, United States.
  • McCormick M; Kitware, Inc., Carrboro, United States.
  • Parkinson H; Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Rosenthal PB; Structural Biology of Cells and Viruses, Francis Crick Institute, London, United Kingdom.
  • Saalfeld S; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
  • Saibil HR; Institute of Structural and Molecular Biology, Department of Crystallography, Birkbeck College, London, United Kingdom.
  • Sarntivijai S; Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Solanes Valero I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Subramaniam S; Laboratory for Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
  • Swedlow JR; Centre for Gene Regulation and Expression and the Division of Computational Biology, University of Dundee, Dundee, United Kingdom.
  • Tudose I; Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
  • Winn M; Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot, United Kingdom.
  • Kleywegt GJ; Molecular and Cellular Structure Cluster, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Elife ; 62017 07 06.
Article em En | MEDLINE | ID: mdl-28682240
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biologia Computacional / Biologia Celular / Substâncias Macromoleculares Idioma: En Revista: Elife Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biologia Computacional / Biologia Celular / Substâncias Macromoleculares Idioma: En Revista: Elife Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido