Clinical Study of Bone Regeneration by Conditioned Medium From Mesenchymal Stem Cells After Maxillary Sinus Floor Elevation.
Implant Dent
; 26(4): 607-612, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28727618
ABSTRACT
OBJECTIVE:
This clinical study was undertaken to evaluate the safety of use of the secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) for maxillary sinus floor elevation (SFE). MATERIALS ANDMETHODS:
MSC-CM was prepared from conditioned medium from human bone marrow-derived MSCs. Six partially edentulous patients were enrolled in the study. MSC-CM was mixed with porous beta-tricalcium phosphate (ß-TCP) and implanted in 4 patients (experimental group), whereas only ß-TCP was implanted in the other 2 patients (control group). Six months after SFE, bone biopsies and histological assessments were performed.RESULTS:
Bone formation was clinically confirmed in all cases. Although Hounsfield units in computed tomography images were not significantly different between the groups, histological analysis revealed a significant difference in newly formed bone area between the groups. In particular, bone volume in the center of the augmented area was significantly greater in the MSC-CM group. Newly formed bone consisted of lamellar bone in the MSC-CM group but woven bone in the ß-TCP group.CONCLUSION:
The secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) was used safely and has great osteogenic potential for regenerative medicine of bone.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração Óssea
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Meios de Cultivo Condicionados
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Transplante de Células-Tronco Mesenquimais
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Células-Tronco Mesenquimais
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Levantamento do Assoalho do Seio Maxilar
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Implant Dent
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article