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Enantioselective Synthesis of Spiro[indolizidine-1,3'-oxindoles].
Pérez, Maria; Ramos, Carlos; Massi, Lucia; Gazzola, Silvia; Taglienti, Chiara; Yayik, Nihan; Molins, Elies; Viayna, Antonio; Luque, F Javier; Bosch, Joan; Amat, Mercedes.
Afiliação
  • Pérez M; Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 08921 Santa Coloma de Gramenet, Spain.
  • Ramos C; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
  • Massi L; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
  • Gazzola S; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
  • Taglienti C; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
  • Yayik N; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
  • Molins E; Institut de Ciència de Materials de Barcelona (ICMAB, CSIC), Campus UAB, 08193 Bellaterra, Spain.
  • Viayna A; Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 08921 Santa Coloma de Gramenet, Spain.
  • Luque FJ; Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 08921 Santa Coloma de Gramenet, Spain.
  • Bosch J; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
  • Amat M; Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona , 080028 Barcelona, Spain.
Org Lett ; 19(15): 4050-4053, 2017 08 04.
Article em En | MEDLINE | ID: mdl-28731721
ABSTRACT
A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic δ-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Espanha
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Espanha