Redox-responsive xanthene-coumarin-chlorambucil-based FRET-guided theranostics for "activatable" combination therapy with real-time monitoring.
Chem Commun (Camb)
; 53(65): 9109-9112, 2017 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-28759056
A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The "locked" FRET pair was selectively "unlocked" by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Umbeliferonas
/
Xantenos
/
Pró-Fármacos
/
Clorambucila
Limite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Índia