Dissecting Glioma Invasiveness in a 3D-Organotypic Model.

Codega, Paolo; Mellinghoff, Ingo K

Codega, Paolo; Mellinghoff, Ingo K.

Afiliação

Codega P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Mellinghoff IK; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address: mellingi@mskcc.org.

Trends Mol Med ; 23(9): 776-777, 2017 09.

Article em En | MEDLINE | ID: mdl-28781061

ABSTRACT

ABSTRACT

Diffuse brain infiltration by tumor cells is a hallmark of glioma. Molecular mechanisms of brain invasion are poorly understood due to the difficulty to model this process in culture. A new study published in Cell Reports developed a three-dimensional organotypic model and identified interferon regulatory factor 3 (IRF3) as repressor of glioma invasion.

Assuntos

Neoplasias Encefálicas; Fator Regulador 3 de Interferon; Modelos Biológicos; Proteínas de Neoplasias; Animais; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/patologia; Glioma; Humanos; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Invasividade Neoplásica; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Fator Regulador 3 de Interferon / Modelos Biológicos / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Trends Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google