'Hummingbird' Sign in a Patient with Guam Parkinsonism-Dementia Complex.
J Mov Disord
; 10(3): 145-148, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28782342
ABSTRACT
We present a case of a 71-year-old male Chamorro patient from Guam who presented with progressive supranuclear palsy (PSP)-Richardson's syndrome. Considering his strong family history of parkinsonism and a PSP phenotype, he was clinically diagnosed with Guam parkinsonism-dementia complex (PDC). Magnetic resonance imaging (MRI) of the brain revealed prominent midbrain atrophy with preserved pontine volume, forming the 'hummingbird' sign, which has not been described before in Guam PDC. Molecular analysis of the chromosome 9 open reading frame 72 gene (C9orf72) showed only 6 GGGGCC repeats. We discuss the clinico-pathological similarities and differences between PSP and Guam PDC, and highlight the topography of neuropathological changes seen in Guam PDC to explain the appearance of the 'hummingbird' sign on MRI.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
J Mov Disord
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Singapura