Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps.
World J Gastroenterol
; 23(28): 5206-5215, 2017 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-28811715
ABSTRACT
AIM:
To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps.METHODS:
A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colonoscopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps.RESULTS:
The prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95%CI 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95%CI 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95%CI 1.18-2.00, P < 0.05; OR = 1.42, 95%CI 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95%CI 0.18-1.04, P > 0.05; OR = 1.18, 95%CI 0.50-2.78, P > 0.05).CONCLUSION:
NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Pólipos do Colo
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Colo
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Pólipos Adenomatosos
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Hepatopatia Gordurosa não Alcoólica
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
World J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China