We Can Still Be Friends: IFN-Î³ Breaks Up Macrophage Enhancers.

Novakovic, Boris; Wang, Cheng; Logie, Colin

Novakovic, Boris; Wang, Cheng; Logie, Colin.

Afiliação

Novakovic B; Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
Wang C; Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
Logie C; Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. Electronic address: c.logie@science.ru.nl.

Immunity ; 47(2): 209-211, 2017 08 15.

Article em En | MEDLINE | ID: mdl-28813650

ABSTRACT

ABSTRACT

Interferon (IFN)-Î³ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-Î³-mediated gene repression as they show that IFN-Î³ promotes the disassembly of select active enhancers by interfering with enhancer-binding transcription factor MAF.

Assuntos

Interferon gama/imunologia; Macrófagos/imunologia; Amigos; Humanos; Ativação de Macrófagos/imunologia; Sequências Reguladoras de Ácido Nucleico; Ativação Transcricional

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferon gama / Macrófagos Limite: Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda

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