SEX STEROIDS AND MACULAR TELANGIECTASIA TYPE 2.
Retina
; 38 Suppl 1: S61-S66, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-28837534
ABSTRACT
PURPOSE:
To investigate the relationship between macular telangiectasia Type 2 and systemic levels of sex steroids or their antagonization.METHODS:
In a prospective single-center study, 90 patients with macular telangiectasia Type 2 were investigated. Female patients were evaluated for previous surgical (e.g., ovariectomy) and/or pharmacological (e.g., aromatase inhibitors, tamoxifen) therapy resulting in reduced action of sex steroids. In males, free serum testosterone levels were assessed in patients and controls.RESULTS:
Fourteen of 49 (29%) female patients had a history of pharmacological suppression of sex steroids and/or ovariectomy. These patients were younger at disease onset when compared with those without such medical history (mean ± SD 47.1 ± 7.8, range 38-59, versus 60.1 ± 7.6, range 45-76; P < 0.0001). Male patients showed significantly lower free serum testosterone levels compared with controls at younger age (P < 0.0001 and 0.04 in the first and second age quartiles, respectively), as opposed to nonsignificant differences in older patients. In men ≤ 60 years of age, a biochemical hypogonadism (free serum testosterone < 0.05 ng/mL) was present in 53% (8/15) and 4% (2/49) of patients and controls, respectively (P < 0.0001).CONCLUSION:
The results indicate that steroidal sex hormones might be involved in the presumably multifactorial pathophysiology of macular telangiectasia Type 2.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hormônios Esteroides Gonadais
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Telangiectasia Hemorrágica Hereditária
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Acuidade Visual
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Retina
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha