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Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation.
Stylos, Evgenios; Chatziathanasiadou, Maria V; Tsiailanis, Antonis; Kellici, Tahsin F; Tsoumani, Maria; Kostagianni, Androniki D; Deligianni, Maria; Tselepis, Alexandros D; Tzakos, Andreas G.
Afiliação
  • Stylos E; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece; Biotechnology Laboratory, Department of Biological Applications and Technology, University of Ioannina, Ioannina 45110, Greece.
  • Chatziathanasiadou MV; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
  • Tsiailanis A; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
  • Kellici TF; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Greece.
  • Tsoumani M; Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
  • Kostagianni AD; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
  • Deligianni M; Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
  • Tselepis AD; Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
  • Tzakos AG; Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece. Electronic address: agtzakos@gmail.com.
Biochim Biophys Acta Gen Subj ; 1861(11 Pt A): 2609-2618, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28844979
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Doenças Cardiovasculares / Flavanonas / Receptor PAR-1 / Ciclo-Oxigenase 1 / Receptores Purinérgicos P2Y12 Limite: Humans Idioma: En Revista: Biochim Biophys Acta Gen Subj Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Grécia
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Doenças Cardiovasculares / Flavanonas / Receptor PAR-1 / Ciclo-Oxigenase 1 / Receptores Purinérgicos P2Y12 Limite: Humans Idioma: En Revista: Biochim Biophys Acta Gen Subj Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Grécia