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The clinical recovery of tuberculosis patients undergoing specific treatment is associated with changes in the immune and neuroendocrine responses.
Díaz, Ariana; Bongiovanni, Bettina; D'Attilio, Luciano; Santucci, Natalia; Dídoli, Griselda; Fernández, Rocío Del Valle; Kovalevski, Leandro; Lioi, Susana; Gardeñez, Walter; Brandan, Nadia; Nannini, Luis J; Besedovsky, Hugo; Del Rey, Adriana; Bottasso, Oscar; Bay, María Luisa.
Afiliação
  • Díaz A; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • Bongiovanni B; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • D'Attilio L; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • Santucci N; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • Dídoli G; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • Fernández RDV; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • Kovalevski L; Facultad de Ciencias Económicas y Estadística, UNR, Escuela de Estadística, 2000 Rosario, Santa Fe, Argentina.
  • Lioi S; Laboratorio Central Rosario, Hospital Provincial del Centenario, 2000 Rosario, Santa Fe, Argentina.
  • Gardeñez W; Servicio de Neumonología, Hospital Provincial del Centenario, 2000 Rosario, Santa Fe, Argentina.
  • Brandan N; Servicio de Neumonología, Hospital Escuela Eva Perón, 2152 Granadero Baigorria, Santa Fe, Argentina.
  • Nannini LJ; Servicio de Neumonología, Hospital Escuela Eva Perón, 2152 Granadero Baigorria, Santa Fe, Argentina.
  • Besedovsky H; Institute of Physiology and Pathophysiology, Philipps University, Faculty of Medicine, 35037 Marburg, Germany.
  • Del Rey A; Institute of Physiology and Pathophysiology, Philipps University, Faculty of Medicine, 35037 Marburg, Germany.
  • Bottasso O; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
  • Bay ML; Instituto de Inmunología Clínica y Experimental de Rosario, UNR-CONICET, 2000 Rosario, Santa Fe, Argentina.
Pathog Dis ; 75(7)2017 09 29.
Article em En | MEDLINE | ID: mdl-28854691
ABSTRACT
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a health problem worldwide. Patients with pulmonary TB show a neuro-immune-endocrine imbalance characterized by an impaired cellular immunity together with increased plasma levels of cortisol, pro- and anti-inflammatory cytokines and markedly decreased dehydroepiandrosterone (DHEA) levels. Extending these findings, we now investigated the immune-endocrine profile of TB patients undergoing specific treatment. Patients (n = 24) were bled at diagnosis (T0), 2, 4, 6 months after treatment initiation and 3 months following its completion. At T0, TB patients showed increased plasma levels of interleukin-6 (IL-6), C reactive protein, interferon-gamma (IFN-γ) and transforming growth factor beta (TGF-ß). These mediators decreased during treatment, reaching levels similar to those from healthy controls (n = 26). Specific treatment led to an increased lymphoproliferative response along with clinical improvement. Newly diagnosed patients had low levels of DHEA, with increased cortisol amounts and cortisol/DHEA ratio, which normalized upon specific treatment. As regards glucocorticoid receptors (GR), TB patients at diagnosis presented a reduced mRNA GRα/GRß ratio in their peripheral blood mononuclear cells. Furthermore, multivariate analysis showed that cortisol/DHEA ratio was positively associated with inflammatory mediators for which this ratio may constitute a disease biomarker. Anti-mycobacterial treatment results in a better immune-endocrine scenario for the control of physiopathological processes accompanying disease development and hence implied in clinical recovery.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Leucócitos Mononucleares / Regulação da Expressão Gênica / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Pathog Dis Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Leucócitos Mononucleares / Regulação da Expressão Gênica / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Pathog Dis Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina