Effects of Calcium-Channel Blocker Benidipine-Based Combination Therapy on Cardiac Eventsã- Subanalysis of the COPE Trial.
Circ J
; 82(2): 457-463, 2018 01 25.
Article
em En
| MEDLINE
| ID: mdl-28867690
ABSTRACT
BACKGROUND:
The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) trial was conducted to compare the effects of regimens combining the dihydropyridine calcium-channel blocker benidipine with each of 3 secondary agent types (an angiotensin-receptor blocker (ARB), a ß-blocker and a thiazide) in Japanese hypertensive outpatients who did not achieve target blood pressure (<140/90 mmHg) with benidipine 4 mg/day alone. The analysis included 3,293 patients (ARB, 1,110; ß-blocker, 1,089; thiazide, 1,094) with a median follow-up of 3.61 years. The main results of the COPE trial demonstrated that the incidences of hard cardiovascular composite endpoints and fatal or non-fatal strokes were significantly higher in the benidipine/ß-blocker group than in the benidipine/thiazide group.MethodsâandâResults:
We further evaluated the treatment effects on different cardiac events among the 3 benidipine-based regimens.We observed a total of 50 cardiac events, 4.2 per 1000 person-years. The incidences of total cardiac events and each cardiac event were similarly low among the 3 treatment groups. Unadjusted and multi-adjusted hazard ratios for total cardiac events showed no significant difference among the 3 treatment groups.CONCLUSIONS:
This subanalysis of the COPE trial demonstrated that blood pressure-lowering regimens combining benidipine with an ARB, ß-blocker or thiazide diuretic were similarly effective for the prevention of cardiac events in Japanese hypertensive outpatients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Di-Hidropiridinas
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Bloqueadores dos Canais de Cálcio
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Quimioterapia Combinada
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Cardiopatias
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Circ J
Assunto da revista:
ANGIOLOGIA
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CARDIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article