Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.

Desmyter, Aline; Spinelli, Silvia; Boutton, Carlo; Saunders, Michael; Blachetot, Christophe; de Haard, Hans; Denecker, Geertrui; Van Roy, Maarten; Cambillau, Christian; Rommelaere, Heidi

Desmyter, Aline; Spinelli, Silvia; Boutton, Carlo; Saunders, Michael; Blachetot, Christophe; de Haard, Hans; Denecker, Geertrui; Van Roy, Maarten; Cambillau, Christian; Rommelaere, Heidi.

Afiliação

Desmyter A; Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Centre National de la Recherche Scientifique (CNRS), Marseille, France.
Spinelli S; Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix-Marseille Université, Marseille, France.
Boutton C; Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Centre National de la Recherche Scientifique (CNRS), Marseille, France.
Saunders M; Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix-Marseille Université, Marseille, France.
Blachetot C; Ablynx N.V., Ghent, Belgium.
de Haard H; Ablynx N.V., Ghent, Belgium.
Denecker G; Ablynx N.V., Ghent, Belgium.
Van Roy M; Ablynx N.V., Ghent, Belgium.
Cambillau C; Ablynx N.V., Ghent, Belgium.
Rommelaere H; Ablynx N.V., Ghent, Belgium.

Front Immunol ; 8: 884, 2017.

Article em En | MEDLINE | ID: mdl-28871249

Palavras-chave

anti-inflammatory; crystal structure; interleukin 23; multivalent binder; nanobody

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Immunol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França

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