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A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer.
O'Sullivan, Dermot; Dowling, Paul; Joyce, Helena; McAuley, Edel; McCann, Andrew; Henry, Michael; McGovern, Brianan; Barham, Paul; Kelleher, Fergal C; Murphy, Jean; Kennedy, Susan; Swan, Niall; Moriarty, Michael; Clynes, Martin; Larkin, Annemarie.
Afiliação
  • O'Sullivan D; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Dowling P; Department of Biology, National University of Ireland - Maynooth, Co. Kildare, Ireland.
  • Joyce H; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • McAuley E; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • McCann A; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Henry M; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • McGovern B; Department of Histopathology, St. Vincents' University Hospital, Elm Park, Dublin 4, Ireland.
  • Barham P; School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Kelleher FC; Department of Medical Oncology, St. Vincents' University Hospital, Elm Park, Dublin 4, Ireland.
  • Murphy J; Department of Histopathology, St. Vincents' University Hospital, Elm Park, Dublin 4, Ireland.
  • Kennedy S; Department of Histopathology, St. Vincents' University Hospital, Elm Park, Dublin 4, Ireland.
  • Swan N; Department of Histopathology, St. Vincents' University Hospital, Elm Park, Dublin 4, Ireland.
  • Moriarty M; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Clynes M; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Larkin A; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
Br J Cancer ; 117(9): 1326-1335, 2017 Oct 24.
Article em En | MEDLINE | ID: mdl-28881357

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Neoplasias da Mama / Carcinoma de Células Escamosas / Biomarcadores Tumorais / Anexina A6 / Carcinoma Ductal Pancreático / Neoplasias Pulmonares / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Br J Cancer Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Irlanda

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Neoplasias da Mama / Carcinoma de Células Escamosas / Biomarcadores Tumorais / Anexina A6 / Carcinoma Ductal Pancreático / Neoplasias Pulmonares / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Br J Cancer Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Irlanda