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Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates.
Kanfar, Nasreddine; Mehdi, Ahmad; Dumy, Pascal; Ulrich, Sébastien; Winum, Jean-Yves.
Afiliação
  • Kanfar N; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, 240 avenue du professeur Emile Jeanbrau, 34296, Montpellier Cedex, France.
  • Mehdi A; Institut Charles Gerhardt Montpellier (ICGM), UMR 5253 CNRS, ENSCM, Université de Montpellier, Place Eugène Bataillon, 34090, Montpellier, France.
  • Dumy P; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, 240 avenue du professeur Emile Jeanbrau, 34296, Montpellier Cedex, France.
  • Ulrich S; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, 240 avenue du professeur Emile Jeanbrau, 34296, Montpellier Cedex, France.
  • Winum JY; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, 240 avenue du professeur Emile Jeanbrau, 34296, Montpellier Cedex, France.
Chemistry ; 23(71): 17867-17869, 2017 Dec 19.
Article em En | MEDLINE | ID: mdl-28892198
The straightforward access to octafunctional "cubic" silsesquioxane platform grafter with pendant glyoxylic aldehydes is described. This clickable hybrid platform readily reacts with oxyamine or hydrazide compounds to provide, respectively, oxime and acylhydrazone conjugates, thereby offering a new and effective access from which one can elaborate multivalent systems for the targeting of biomolecules of interest.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Organossilício / Aldeídos Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Organossilício / Aldeídos Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França