Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia and Helicobacter pylori Infection.
Gut Liver
; 12(2): 158-164, 2018 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-28918609
ABSTRACT
BACKGROUND/AIMS:
Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection.METHODS:
Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1ß levels were measured.RESULTS:
The mean pH of gastric juice was higher in the H. pylori-positive group (n=17) than that in the H. pylori-negative group (n=29) (4.54 vs 2.46, p=0.002). When patients were divided into pH ï¼3 (n=28) and pH ≥3 (n=18) groups, H. pylori was lower in the pH ï¼3 group (21.4%) than in the pH ≥3 group (61.1%) (p=0.007). The pH ≥3 group demonstrated AG and IM more frequently than the pH ï¼3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum. There were no differences in pepsinogen I or II, I/II ratio, and IL-1ß levels between the two groups.CONCLUSIONS:
There is a relationship between chronic H. pylori infection and gastric juice pH ≥3, which may originate from AG and IM in the body.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Helicobacter pylori
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Pepsinogênio A
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Suco Gástrico
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Gastrite Atrófica
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Mucosa Intestinal
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Gut Liver
Ano de publicação:
2018
Tipo de documento:
Article