MK5: A novel regulator of cardiac fibroblast function?
IUBMB Life
; 69(10): 785-794, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28941148
ABSTRACT
MAP kinase-activated protein kinases (MKs), protein serine/threonine kinases downstream of the MAPKs, regulate a number of biological functions. MK5 was initially identified as a substrate for p38 MAPK but subsequent studies revealed that MK5 activity is regulated by atypical MAPKs ERK3 and ERK4. However, the roles of these MAPKs in activating MK5 remain controversial. The interactome and physiological function of MK5 are just beginning to be understood. Here, we provide an overview of the structure-function of MK5 including recent progress in determining its role in cardiac structure and function. The cardiac phenotype of MK5 haplodeficient mice, and the effect of reduced MK5 expression on cardiac remodeling, is also discussed. © 2017 IUBMB Life, 69(10)785-794, 2017.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Serina-Treonina Quinases
/
Proteína Quinase 6 Ativada por Mitógeno
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Proteínas Quinases p38 Ativadas por Mitógeno
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Peptídeos e Proteínas de Sinalização Intracelular
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Fibroblastos
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Ventrículos do Coração
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Miocárdio
Limite:
Animals
/
Humans
Idioma:
En
Revista:
IUBMB Life
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá