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Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic.
Nicol, Dianne; Eckstein, Lisa; Morrison, Michael; Sherkow, Jacob S; Otlowski, Margaret; Whitton, Tess; Bubela, Tania; Burdon, Kathryn P; Chalmers, Don; Chan, Sarah; Charlesworth, Jac; Critchley, Christine; Crossley, Merlin; de Lacey, Sheryl; Dickinson, Joanne L; Hewitt, Alex W; Kamens, Joanne; Kato, Kazuto; Kleiderman, Erika; Kodama, Satoshi; Liddicoat, John; Mackey, David A; Newson, Ainsley J; Nielsen, Jane; Wagner, Jennifer K; McWhirter, Rebekah E.
Afiliação
  • Nicol D; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, 7001, Australia. Dianne.Nicol@utas.edu.au.
  • Eckstein L; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, 7001, Australia.
  • Morrison M; Centre for Health, Law and Emerging Technologies, Nuffield Department of Population Health, University of Oxford, Oxford, OX2 7DD, UK.
  • Sherkow JS; Innovation Center for Law and Technology, New York Law School, New York, 10013, USA.
  • Otlowski M; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, 7001, Australia.
  • Whitton T; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, 7001, Australia.
  • Bubela T; Menzies Institute for Medical Research, University of Tasmania, Hobart, 7000, Australia.
  • Burdon KP; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A1S6, Canada.
  • Chalmers D; Menzies Institute for Medical Research, University of Tasmania, Hobart, 7000, Australia.
  • Chan S; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, 7001, Australia.
  • Charlesworth J; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9YL, UK.
  • Critchley C; Menzies Institute for Medical Research, University of Tasmania, Hobart, 7000, Australia.
  • Crossley M; Department of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Melbourne, 3122, Australia.
  • de Lacey S; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052, Australia.
  • Dickinson JL; School of Nursing and Midwifery, Flinders University, Adelaide, 5042, Australia.
  • Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, 7000, Australia.
  • Kamens J; Menzies Institute for Medical Research, University of Tasmania, Hobart, 7000, Australia.
  • Kato K; Addgene, Cambridge, 02139, USA.
  • Kleiderman E; Department of Biomedical Ethics and Public Policy, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Kodama S; Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, H3A0G4, Canada.
  • Liddicoat J; Department of Ethic, Graduate School of Letters, Kyoto University, Kyoto, 606-8501, Japan.
  • Mackey DA; Faculty of Law, University of Cambridge, Cambridge, CB3 9DZ, UK.
  • Newson AJ; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, 6009, Australia.
  • Nielsen J; Sydney Health Ethics, Sydney School of Public Health, University of Sydney, Sydney, 2006, Australia.
  • Wagner JK; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, 7001, Australia.
  • McWhirter RE; Center for Translational Bioethics & Health Care Policy, Geisinger Health System, Danville, PA, 17822, USA.
Genome Med ; 9(1): 85, 2017 09 25.
Article em En | MEDLINE | ID: mdl-28946923
ABSTRACT
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia Baseada em Transplante de Células e Tecidos / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Genome Med Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia Baseada em Transplante de Células e Tecidos / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Genome Med Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália