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Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.
Eloy, Philippine; Tessier, Adrien; Fan-Havard, Patty; Chou, Monidarin; Verstuyft, Céline; Taburet, Anne-Marie; Haas, David W; Bertrand, Julie.
Afiliação
  • Eloy P; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
  • Tessier A; Division of Clinical Pharmacokinetics and Pharmacometrics, Institut de Recherches Internationales Servier, Suresnes, France.
  • Fan-Havard P; School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Amherst, New York, USA.
  • Chou M; College of Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Verstuyft C; Rodolphe Mérieux Laboratory, Faculty of Pharmacy, University of Health Sciences, Phnom Penh, Cambodia.
  • Taburet AM; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Haas DW; INSERM U1184, Le Kremlin-Bicêtre, France.
  • Bertrand J; Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Hôpital de Bicêtre, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France.
Antimicrob Agents Chemother ; 61(12)2017 12.
Article em En | MEDLINE | ID: mdl-28947469
ABSTRACT
Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between CYP2B6 polymorphisms and metabolite ratios for both 3-hydroxynevirapine and 8-hydroxynevirapine, suggesting involvement of CYP2B6 in generating these metabolites.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV / Nevirapina / Citocromo P-450 CYP2B6 Limite: Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV / Nevirapina / Citocromo P-450 CYP2B6 Limite: Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França