Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands.
Exp Eye Res
; 163: 58-63, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28950938
ABSTRACT
The epidermal growth factor receptor (EGFR) signaling has a pivotal role in the regulation of morphogenesis during development and maintenance of homeostasis in adult eyelid and its adnexa. Studies have demonstrated that during eyelid morphogenesis the EGFR signaling pathway is responsible for keratinocyte and mesenchymal cell proliferation and migration at the eyelid tip. For meibomian gland morphogenesis, EGFR signaling activation stimulates meibomian gland epithelial cell proliferation. EGFR signaling pathway functions through multiple downstream signals such as ERK, Rho/ROCK and integrin and is regulated by a variety of upstream signals including Adam17, GPR48 and FGFR signaling. Herein we review the literature that describe the role of EGFR and its related signaling pathways in eyelid and meibomian gland morphogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pálpebras
/
Receptores ErbB
/
Glândulas Tarsais
Limite:
Humans
Idioma:
En
Revista:
Exp Eye Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos