Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil.
Mem Inst Oswaldo Cruz
; 112(10): 728-731, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28954002
ABSTRACT
The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Doenças do Colo do Útero
/
Genoma Viral
/
Infecções por Papillomavirus
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil