Non-parametric graphnet-regularized representation of dMRI in space and time.
Med Image Anal
; 43: 37-53, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28982075
ABSTRACT
Effective representation of the four-dimensional diffusion MRI signal - varying over three-dimensional q-space and diffusion time τ - is a sought-after and still unsolved challenge in diffusion MRI (dMRI). We propose a functional basis approach that is specifically designed to represent the dMRI signal in this qτ-space. Following recent terminology, we refer to our qτ-functional basis as "qτ-dMRI". qτ-dMRI can be seen as a time-dependent realization of q-space imaging by Paul Callaghan and colleagues. We use GraphNet regularization - imposing both signal smoothness and sparsity - to drastically reduce the number of diffusion-weighted images (DWIs) that is needed to represent the dMRI signal in the qτ-space. As the main contribution, qτ-dMRI provides the framework to - without making biophysical assumptions - represent the qτ-space signal and estimate time-dependent q-space indices (qτ-indices), providing a new means for studying diffusion in nervous tissue. We validate our method on both in-silico generated data using Monte-Carlo simulations and an in-vivo test-retest study of two C57Bl6 wild-type mice, where we found good reproducibility of estimated qτ-index values and trends. In the hopes of opening up new τ-dependent venues of studying nervous tissues, qτ-dMRI is the first of its kind in being specifically designed to provide open interpretation of the qτ-diffusion signal.
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Base de dados:
MEDLINE
Assunto principal:
Imagem de Difusão por Ressonância Magnética
Tipo de estudo:
Health_economic_evaluation
Limite:
Animals
Idioma:
En
Revista:
Med Image Anal
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2018
Tipo de documento:
Article