A high-coverage Neandertal genome from Vindija Cave in Croatia.
Science
; 358(6363): 655-658, 2017 11 03.
Article
em En
| MEDLINE
| ID: mdl-28982794
ABSTRACT
To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Evolução Biológica
/
Homem de Neandertal
Limite:
Animals
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Science
Ano de publicação:
2017
Tipo de documento:
Article