Safety of leucodepleted salvaged blood in oncological surgery: an in vitro model.
Vox Sang
; 112(8): 803-805, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28983930
ABSTRACT
Intra-operative blood cell salvage (IOCS) is mainly avoided in onco surgery due to the suspicion that it could increase metastasis' risk. We simulated IOCS followed by leucodepletion HCT116 (human colorectal cancer) cells were inoculated into packed red blood cells units, and their distribution was evaluated, step-by-step, by flow cytometry and immunohistochemistry. Most of HCT116 cells were lost during washing, and almost completely removed after filtration. IOCS plus leucodepletion could be of great advantage for oncological patients, where allogenic blood transfusion could influence tumour progression.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reação Transfusional
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Vox Sang
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Itália