[Mechanism of migration and release of high mobility group box-1].

Zhao, Xin; Lü, Ben; Wang, Erhua

Zhao, Xin; Lü, Ben; Wang, Erhua.

Afiliação

Zhao X; Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013; Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
Lü B; Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013; Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
Wang E; Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 42(9): 1111-1115, 2017 Sep 28.

Article em Zh | MEDLINE | ID: mdl-28989160

ABSTRACT

ABSTRACT

High mobility group box-1 (HMGB1) is an evolutionarily conserved protein, which widely exists in mammals. HMGB1 contains the nucleus localization sequences. Intracellular and extracellular HMGB1 shows different biological functions. Extracellular HMGB1 is closely related to sepsis, cancer, rheumatoid immune, atherosclerosis, ischemia-reperfusion injury and so on. The mobilization of HMGB1 from the nucleus to the cytoplasm and subsequent release involves the processes of post-translation modification, active secretion and nuclear localization.

Assuntos

Proteína HMGB1; Transporte Proteico; Animais; Núcleo Celular/metabolismo; Citoplasma/metabolismo; Proteína HMGB1/metabolismo; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transporte Proteico / Proteína HMGB1 Limite: Animals / Humans Idioma: Zh Revista: Zhong Nan Da Xue Xue Bao Yi Xue Ban Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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