Cost-Benefit Analysis of a Chlamydia trachomatis Vaccine Program in Adolescent Girls in the United States.
J Pediatric Infect Dis Soc
; 7(4): 296-302, 2018 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-28992068
ABSTRACT
BACKGROUND:
With >1.4 million cases in the United States reported to the Centers for Disease Control and Prevention in 2012, Chlamydia trachomatis infection is a major public health concern. We examined the impact of a C trachomatis vaccination program using a decision-analysis model to estimate the effects of vaccination on C trachomatis-associated costs and morbidity.METHODS:
We developed a Markov model considering a cohort of 2158117 US females aged 9 to 26 years. Morbidity, death, and healthcare-associated costs associated with chlamydial infection of mothers and fetuses/neonates were calculated over a 17-year time frame. We developed 2 major comparison arms, namely, a C trachomatis vaccination program and no C trachomatis vaccination program. Base-case efficacy and coverage were set to those of human papillomavirus in the United States with all variables, including efficacy and coverage, ranged in sensitivity analyses.RESULTS:
On the basis of a base-case analysis, a vaccination program would cost an estimated $710 million for a cohort of 2158117 women over a 17-year period, an increase of $41 million over having no vaccination program. A vaccination program would prevent 34000 cases of C trachomatis infection and 5976 cases of pelvic inflammatory disease.CONCLUSIONS:
A C trachomatis vaccination program results in increased cost to the healthcare system but averts significant morbidity and death.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas Bacterianas
/
Infecções por Chlamydia
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Chlamydia trachomatis
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Vacinação em Massa
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Técnicas de Apoio para a Decisão
/
Análise Custo-Benefício
Tipo de estudo:
Health_economic_evaluation
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Ano de publicação:
2018
Tipo de documento:
Article