Zn(OTf)2-Catalyzed Phosphinylation of Propargylic Alcohols: Access to γ-Ketophosphine Oxides.
J Org Chem
; 82(21): 11659-11666, 2017 11 03.
Article
em En
| MEDLINE
| ID: mdl-29019674
ABSTRACT
The first facile and efficient Zn(OTf)2-catalyzed direct coupling of unprotected propargylic alcohols with arylphosphine oxides has been developed, affording a general, one-step approach to access structurally diverse γ-ketophosphine oxides via sequential Meyer-Schuster rearrangement/phospha-Michael reaction along with new C(sp3)-P and CâO bond formations, operational simplicity, and complete atom economy under ligand-free and base-free conditions.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China