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Zn(OTf)2-Catalyzed Phosphinylation of Propargylic Alcohols: Access to γ-Ketophosphine Oxides.
Shan, Changkai; Chen, Fushan; Pan, Jiaoting; Gao, Yuxing; Xu, Pengxiang; Zhao, Yufen.
Afiliação
  • Shan C; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, 361005 Fujian, China.
  • Chen F; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, 361005 Fujian, China.
  • Pan J; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, 361005 Fujian, China.
  • Gao Y; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, 361005 Fujian, China.
  • Xu P; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, 361005 Fujian, China.
  • Zhao Y; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, 361005 Fujian, China.
J Org Chem ; 82(21): 11659-11666, 2017 11 03.
Article em En | MEDLINE | ID: mdl-29019674
ABSTRACT
The first facile and efficient Zn(OTf)2-catalyzed direct coupling of unprotected propargylic alcohols with arylphosphine oxides has been developed, affording a general, one-step approach to access structurally diverse γ-ketophosphine oxides via sequential Meyer-Schuster rearrangement/phospha-Michael reaction along with new C(sp3)-P and C═O bond formations, operational simplicity, and complete atom economy under ligand-free and base-free conditions.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China