Galectin-3 Reflects Left Atrial Function being Assessed by Cardiac Magnetic Resonance Imaging.
Clin Lab
; 63(10): 1701-1710, 2017 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-29035464
ABSTRACT
BACKGROUND:
This study aims to evaluate the association between galectin-3 and left atrial function (LAF) in patients undergoing cMRI.METHODS:
Patients undergoing cMRI were prospectively enrolled. Right ventricular dysfunction (< 50%) was excluded. Blood samples for biomarker measurements of galectin-3 and NT-proBNP were collected at the time of cMRI examination.RESULTS:
A total of 84 patients were included. Median LVEF was 59% (IQR 51 - 64%). Galectin-3 was inversely correlated with overall LAF within a multivariable linear regression model (Beta -0.27; T -2.54; p = 0.01). Galectin-3 increased significantly according to the different stages of impaired LAF (p = 0.003) and was able to discriminate both patients with impaired LAF < 55% (AUC = 0.70, p = 0.002) and LAF < 45% (AUC = 0.69, p = 0.004). In multivariable logistic regression models, galectin-3 was still associated with impaired LAF (LAF < 55% OR = 2.64, p = 0.07; LAF < 45% OR = 6.65, p = 0.007).CONCLUSIONS:
This study demonstrates that galectin-3 is able to reflect LAF being assessed by cMRI.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Função do Átrio Esquerdo
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Galectina 3
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Lab
Assunto da revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2017
Tipo de documento:
Article